Miconazole in Coccidioidomycosis

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Coccidioidomycosis.

Coccidioides immitis and C posadasii are pathogenic dimorphic fungi responsible for causing coccidioidomycosis in the Southwestern United States and Central and South America. Antifungal therapy is beneficial and entails careful periodic assessment with therapies ranging from none or short courses of therapy to prolonged antifungal therapy. Factors that influence the decision to treat are the d...

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Interest in the Incidence of coccidioidomycosis throughout the desert areas of the western slopes of the Rockies and the southwestern desert country has been accelerated by studies made at the airbases and by the many new endemic foci which have been discovered during the past three years. The purpose of this study is to attempt to evaluate the Importance of this infection in the civilian popul...

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BACKGROUND Coccidioidomycosis is a fungal infection acquired via inhalation of airborne fungal arthrospores of Coccidioides species in regions of endemicity in the deserts of the southwestern United States and northern Mexico. In recent years, the incidence of coccidioidomycosis has increased in areas of endemicity, and previous studies have found the highest incidence of coccidioidal infection...

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Bioassay for miconazole.

A radial diffusion bioassay for miconazole, which employs Candida stellatoidea as the indicator organism, is described. Results from three patients treated with the drug are presented.

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Miconazole, a potent antifungal agent, labilizes rat liver lysosomes. Its labilizing effect is followed by measuring the release of lysosomal hydrolases, namely, acid phosphatase, beta-glucuronidase, and arylsulfatase A. The effect of miconazole is concentration dependent in the range of 10(-5) to 1.2 x 10(-4) M. However, at higher concentrations, miconazole inhibits enzyme release but does not...

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ژورنال

عنوان ژورنال: Proceedings of the Royal Society of Medicine

سال: 1977

ISSN: 0035-9157

DOI: 10.1177/00359157770700s105